Lawrence Altman has authored the only complete history of the controversial and understudied practice of self-experimentation. In telling the stories of pioneering researchers, Altman offers a history of many of the most important medical advancements in recent years as well as centuries past—from anesthesia to yellow fever to heart disease. With a new preface, he brings readers up to date and continues his discussion of the ethics and controversy that continue to surround a practice that benefits millions but is understood by few.