O'Manique critically examines the evolution of the policy response to AIDS in Sub-Saharan Africa through a feminist political economy lens, focusing on the relationship between neo-liberalism, the spread of AIDS and the hegemonic policy response. It explores the ways in which AIDS has been constructed as a 'development' problem and how AIDS knowledges and institutions have evolved and have shaped interventions in the AIDS sector. Central to the analysis is a historical case-study of Uganda.