Cover image for The multiprotein complex which interacts with CD36 to generate the pre-chylomicron transport vesicle required for COP2 transport may be of significance in a familial disorder which causes psychosis and in schizophrenia more generally.

The multiprotein complex which interacts with CD36 to generate the pre-chylomicron transport vesicle required for COP2 transport may be of significance in a familial disorder which causes psychosis and in schizophrenia more generally.

by John Neville

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Science / General

Description

It was previously concluded that patterns of genes located at 17q25.3 (the location of PYCR1, SEC24D, the prolyl 4 hydroxylase subunit P4HB and CSNK1D) and 5q31.1 (the location of SAR1B, SEC24A, the prolyl 4 hydroxylase subunit P4HA2 and, at 5q32, CSNK1A) were probably significant in a familial disorder that causes psychosis. This allowed for a prediction that there must be a direct link between PYCR1 function and SAR1B function, as well as a link between SEC24, PYCR1, SAR1B, prolyl 4 hydroxylase subunits and casein kinase 1. Here it is pointed out that CD36 provides this link. Additionally, it was previously noted that SAR1B mediated COP2 transport probably played a significant role in the familial disorder and in schizophrenia more generally. Further evidence is presented that suggests that a novel multiprotein complex which interacts to generate the pre-chylomicron transport vesicle required for COP2 transport is of significance in the familial disorder and in schizophrenia more generally.

Book Details

Publisher:
Lulu.com
Published:
2018-06-18
Pages:
40
Language:
EN
ISBN:
9780244994433