Protein Moonlighting in Biology and Medicine

by Brian Henderson, Mario A. Fares, Andrew C. R. Martin

2016 · John Wiley & Sons

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

U.S. International Exhibitions during the Cold War

by Andrew James Wulf

2015 · Bloomsbury Publishing PLC

Although cultural diplomacy has become an increasingly fashionable term embraced by academics, foreign-service personnel, and private sector commercial and cultural interests, the very practice of this idea remains conspicuously challenging to define. This book takes on this problem, advancing a new understanding of cultural diplomacy that results from a historical investigation of a single area of government and private sector partnership, and what became in the mid-twentieth century the most prominent manifestation of this alliance—the cultural exhibitions sent abroad to “tell America’s story” with the goal of “winning hearts and minds.” To illustrate this point, selected exhibitions and the intentions of the policymakers who proposed them are interrogated for the first time beside archival documentation, writings from the history of design, advertising, science, as well as art historical and museum studies theories that address various aspects of the history of collecting and display, all of which explore the reality of how these exhibitions were conceived and prepared for foreign audiences. Most importantly, personal interviews with the designers and government representatives responsible for the ultimate appearance of these events upturn preconceived notions of how these events came to be. Seventy-five photographs from the exhibits make this history come alive. Through this discussion these questions are answered: What was America showing of itself through these exhibitions? And, more urgently, what do these exhibitions tell us about U.S. interest in verisimilitude? This investigation spans the crucial years of American exhibitions abroad (1955-1975), beginning with the formation of an official system of exhibiting American commercial wares and political ideas at trade fairs, through official exchanges with the U.S.S.R., to pavilions at world's fairs, and finally to museum exhibitions that signaled a return to the display of founding American values. They are thus complex ideological symbols in which concepts of national identity, globalization, technology, consumerism, design, and image management both coincided and clashed. The investigation of these exhibitions enhances the understanding of a significant chapter of U.S. cultural diplomacy at the height of the Cold War and how America constantly reimagined itself.

The Red and the White

by Andrew R. Graybill

2013 · W. W. Norton & Company

Winner of the Labriola Center American Indian National Book Award. One of the American West’s bloodiest—and least-known—massacres is searingly re-created in this generation-spanning history of native-white intermarriage. At dawn on January 23, 1870, four hundred men of the Second U.S. Cavalry attacked and butchered a Piegan camp near the Marias River in Montana in one of the worst slaughters of Indians by American military forces in U.S. history. Coming to avenge the murder of their father—a former fur-trader named Malcolm Clarke who had been killed four months earlier by their Piegan mother’s cousin—Clarke ’s own two sons joined the cavalry in a slaughter of many of their own relatives. In this groundbreaking work of American history, Andrew R. Graybill places the Marias Massacre within a larger, three-generation saga of the Clarke family, particularly illuminating the complex history of native-white intermarriage in the American Northwest.