Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

by Sheila Annie Peters

2012 · John Wiley & Sons

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference a valuable asset for general or novice readers without a PBPK background along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.

Legendary Locals of Newport

by Annie Sherman

2013 · Arcadia Publishing

Established by Colonials seeking religious and cultural freedom in 1639, Newport has enjoyed nearly four centuries of growth--from a thriving seaport to a summer hideaway for industrial revolution excesses, from an active Navy town to a modern world-class destination for sailing and tourism. But beyond the marbled mansions and active harbor-front wharves lie legendary locals building a city of living history, education, arts, and philanthropy. And as this "City-by-the-Sea" celebrates 375 years in 2014, residents honor the diversity of the people who keep it flourishing. Stone carvers John "Fud" Benson and son Nick utilize time-honored techniques etching gravestones and memorials by hand in the oldest trade shop in the country, while nearby, the largest high-tech megayachts in the world dock at the Dana family's Newport Shipyard. Newporter and Navy SEAL Terry Moy helped the last Apollo mission land safely back on Earth, while advocate Florence Gray helped keep affordable housing residents grounded only a few blocks from the city's upscale neighborhoods.