Books by "David C. Kozak"
5 books found
New Treatments of Leukemia and Lymphoma describes the most important advances in the therapy of hematopoietic cancers that have been derived from recent discoveries in cancer cell biology, kinase biochemistry, and immunology. Detailed descriptions of the large number of new and effective agents that have recently become available for the treatment of leukemias and lymphomas as well as an understanding of their mechanisms of action and their integration into current therapy are provided. A number of experimental drug reagents currently in clinical investigation are also discussed. The therapies include conventional anti-metabolites, monoclonal antibodies directed to cell surface receptors, antibodies tagged with toxins and radiopharmaceuticals, inhibitors of specific kinases, stem cell transplants, and engineered T-cells designed to selectively target hematopoietic cancers. The contents of the book will allow practitioners and investigators alike to understand what is current and state of the art as well as what to look for in the future.* Provides an up-to-date, state of the art discussion of a rapidly changing field * Great breadth covering conventional chemotherapeutic agents, biologic agents such as antibodies, novel small molecule inhibitors and genetically engineered cells * Written by international experts in each of the fields
Leadership in Organizations is the first in a series of three books written primarily for distance-learning students in online undergraduate and graduate programs with a focus on management, leadership, and organizational development. This first book introduces concepts, theories, and principles of leadership across a broad spectrum and is intended for students in online courses on leadership, management, and business. A signature theme of the book is the distinction between leadership and management. This book presents a real-world view to help students learn to recognize the dynamics of leadership theory in operation so that they can begin to apply these principles to situations in their work environments.
Targeting Protein Kinases for Cancer Therapy
by David J. Matthews, Mary E. Gerritsen
2011 · John Wiley & Sons
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
How and why are the Kims rational? There is no consensus about either the Kims’ rationality or how best to determine if they are rational actors. Rationality in the North Korean Regime offers a concise and finite method to assess rationality by examining over ten cases of provocations from the Korean War to the August 2015 land mine incident. The book asserts that Kim Il-sung was predominantly a rational actor, though the regime behaved irrationally at times under his rule, and that both Kim Jong-il and Kim Jong-un have clearly been rational actors. As a rational actor, Kim Jong-un is unlikely to give up his nuclear weapons, but this work argues he can be deterred from using them if the United States demonstrates it is willing to co-exist with his regime and pursues long-term engagement to reduce Kim’s concern that North Korea’s sovereignty needs defending from U.S. hostile policy. This could allow gradual social change within the country that could eventually lead to positive systemic change as well as soften Kim’s rule. In this regard, time may be on the side of the U.S.-South Korean alliance, but the two allies must embrace the long view and learn to be more patient or risk another conflict on the Korean Peninsula.
This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.