Neurologic Complications of Cancer Therapy

by Eudocia Quant Lee, David Schiff, Patrick Y. Wen

2011 · Demos Medical Publishing

Neurologic side effects of cancer therapy can inhibit treatment, can be dose-limiting and can diminish quality-of-life. Neurotoxicity related to cancer therapy is a common problem in oncology practice and in clinical neurology. Recognition of neurologic complications of anticancer therapy is necessary due to potential confusion with metastatic disease, paraneoplastic syndromes or comorbid neurologic disorders that do not require reduction or discontinuation of therapy. Neurologic Complications of Cancer Therapy provides comprehensive coverage of the recognition and management of neurologic symptoms related to cancer therapy. The book includes sections on systemic therapy discussed by both agent and adverse event. The section on adverse events is particularly valuable to clinicians, allowing them to consult by symptom in cases where multiple agents have been administered and the source of the complication is uncertain. The systemic therapy section includes coverage of immunologic agents, biologics, and targeted therapies. The book also features sections on the complications of radiation therapy, complications of surgery and high-dose chemotherapy, and stem cell transplantation. Neurologic Complications of Cancer Therapy Features: A widely recognized team of editors Systemic therapy covered by therapeutic agent and by adverse event, enabling a "problem-oriented" approach for the clinician Coverage of newer modalities including immunologic agents, biologics, and targeted therapies Complete sections on complications of radiation therapy, surgery, high-dose chemotherapy, and stem-call transplantion

Complex Disorders in Pediatric Psychiatry

by David I Driver, Shari Thomas

2018 · Elsevier Health Sciences

Get a quick, expert overview of complex childhood psychiatric disorders from Drs. David I. Driver and Shari Thomas of Healthy Foundations Group. This practical resource presents a summary of today's current knowledge and best approaches to topics from gender dysphoria to childhood onset schizophrenia and other complex psychiatric disorders. - Comprehensive guide for any professional working with children. - Consolidates today's evidence-based information on complex childhood psychiatric disorders into one convenient resource. - Provides must-know information on evaluation and management. - Covers a range of psychiatric disorders of children including drug-induced mania and psychosis, concussions, ADHD, technology addiction, sleep disorders, and eating disorders.

Principles of Computational Modelling in Neuroscience

by David Sterratt, Bruce Graham, Andrew Gillies, David Willshaw

2011 · Cambridge University Press

The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signalling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modelling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience.

Train Aerodynamics

by Chris Baker, Terry Johnson, Dominic Flynn, Hassan Hemida, Andrew Quinn, David Soper, Mark Sterling

2019 · Butterworth-Heinemann

Train Aerodynamics: Fundamentals and Applications is the first reference to provide a comprehensive overview of train aerodynamics with full scale data results. With the most up-to-date information on recent advances and the possibilities of improvement in railway facilities, this book will benefit railway engineers, train operators, train manufacturers, infrastructure managers and researchers of train aerodynamics. As the subject of train aerodynamics has evolved slowly over the last few decades with train speeds gradually increasing, and as a result of increasing interest in new train types and high-speed lines, this book provides a timely resource on the topic. - Examines the fundamentals and the state-of-the-art of train aerodynamics, beginning with experimental, numerical and analytical tools, and then thoroughly discussing the specific approaches in other sections - Features the latest developments and progress in computational aerodynamics and experimental facilities - Addresses problems relating to train aerodynamics, from the dimensioning of railway structures and trains, to risk analysis related to safety issues and maintenance - Discusses basic flow patterns caused by bridges and embankments