Books by "John F. Szabo"
5 books found
Innovative Immunotherapy Strategies for Enhanced Treatment of Hodgkin and Non-Hodgkin Lymphomas
by Michael John Robertson
2025 · Frontiers Media SA
Immunotherapy has emerged as a pivotal field in cancer treatment, particularly for lymphomas, which include both Hodgkin and non-Hodgkin variants. Rituximab, a pioneering cancer immunotherapy, remains integral to the treatment regimens for B cell non-Hodgkin lymphomas. Recent advancements have seen the approval of CD19-directed chimeric antigen receptor (CAR) T cell therapies and CD20 x CD3 bispecific antibodies for relapsed and refractory aggressive B cell non-Hodgkin lymphomas. Additionally, immune checkpoint inhibitors and CD30 antibody-drug conjugates have significantly improved treatment outcomes for classical Hodgkin lymphoma. Despite these advancements, the clinical results remain suboptimal, highlighting the need for further enhancement of therapeutic options. Current research is focused on addressing these gaps by exploring novel strategies to bolster both innate and adaptive immune responses against cancer, thereby improving the efficacy of immunotherapy for lymphomas.
Congenital Heart Disease in Adults
by Joseph K. Perloff, John S. Child, Jamil Aboulhosn
2008 · Elsevier Health Sciences
Dr. Perloff, the founding father of the field of adult congenital heart disease, presents a decade's worth of research and clinical data in the completely redefined 3rd edition to bring you the most current information. With advances in diagnosis and treatment in children, more and more of those with CHD survive well into adulthood. Expert contributors in various fields offer a multi-disciplinary, multi-system approach to treatment so you get comprehensive coverage on all aspects of the subspecialty, including basic unoperated malformations, medical and surgical perspectives, postoperative residue, and sequelae. As someone who treats these patients, you need to be ready to provide the continual care they require. Conveys a multidisciplinary, multi-system approach to the lifelong care of adult CHD patients to put treatment in a broader context. Presents information in a consistent, logical style so the information you need is easy to find and apply. Supplements the text with 600 clear conceptual illustrations to clarify difficult concepts. Features completely rewritten chapters to include the latest developments in the field-such as major advances in surgical and interventional techniques-and the various needs of patients with adult CHD. Incorporates recently published trials such as those involving cyanotic CHD and atherogenesis, coronary microcirculation, and pathogenesis of thrombocytopenia to supplement the chapter on cyanotic CHD. Emphasizes advances in imaging in a new section-edited by an expert-that covers echocardiography as well as specialized imaging techniques. Illustrates the full range of advances in the field with 600 images that reflect the latest progress. Includes new chapters-Global Scope of ACHD; Cardiac Transplantation; Electrophysiologic Abnormalities in Unoperated Patients and Residue and Sequelae After Cardiac Surgery-to provide you with the latest information on the growth of the subspecialty and its effect on treatment. Presents revisions by a new authorship of experts in infectious disease, genetics and epidemiology, sports medicine, neurology, cardiac surgery, cardiac anesthesiology, and more.
The end of the Cold War was a "big bang" reminiscent of earlier moments after major wars, such as the end of the Napoleonic Wars in 1815 and the end of the world wars in 1919 and 1945. But what do states that win wars do with their newfound power, and how do they use it to build order? In After Victory, John Ikenberry examines postwar settlements in modern history, arguing that powerful countries do seek to build stable and cooperative relations, but the type of order that emerges hinges on their ability to make commitments and restrain power. He explains that only with the spread of democracy in the twentieth century and the innovative use of international institutions—both linked to the emergence of the United States as a world power—has order been created that goes beyond balance of power politics to exhibit "constitutional" characteristics. Blending comparative politics with international relations, and history with theory, After Victory will be of interest to anyone concerned with the organization of world order, the role of institutions in world politics, and the lessons of past postwar settlements for today.
Provides an overview of the principles, theories, policies, and other fundamentals of modern warfare and their applications in the twenty-first century.
Intended as a practical guide for polymer technologists, engineers and analysts in the plastics, composites and rubber fields, this title describes a range of techniques and strategies for compositional and failure analysis of polymeric materials and products. Numerous examples illustrate the application of analytical methods for solving commonly encountered problems in the polymer industry. The reader is guided towards the most appropriate method of analysis and measurement and the most likely reasons for the failure. Areas covered include: * Migration and interaction of additives * Mechanical stress and stress cracking * Crazing and fracture * Residual stress and weld lines * Contamination and discoloration Numerous pedagogical methods, illustrative flow diagrams, figures and tables are used throughout the text to make it an invaluable guide to all analysts and polymer engineers in industrial or academic laboratories.