Books by "Jonathan G. Herrmann"
4 books found
Immunosuppression and Human Malignancy
by David Naor, Benjamin Y. Klein, Nora Tarcic, Jonathan S. Duke-Cohan
2012 · Springer Science & Business Media
The immune system can deal effectively with the majority of viruses and bacteria, less effectively with parasites, and very poorly with cancer. Why is this so? Why are McFarlane Burnet's and Lewis Thomas' predictions that the immune system is in volved in ridding the body of cancer cells, encapsulated in the catchy phrase "immunologic surveillance," so difficult to experi mentally establish? Cancer differs from infectious agents in being derived from the host. Hence, it has been postulated that cancer cells lack anti gens that the immune system can recognize. They are not "im munogenic. " However, this argument is seriously weakened by the existence of numerous human autoimmune diseases, in which the immune system effectively recognizes and attacks a va riety of self tissues. Thus, the potential clearly exists for recogni tion of the surfaces of tumor cells. Professor Naor and his colleagues have written a book that explores another possible reason: cancer cells are recognized by the immune system-but is it possible that the consequence of recognition is inhibition of the immune system-by suppressor T cells or macrophages? The evolution of the malignant state may only occur in individuals who develop this suppression. This book reviews the evidence that suppressor cells, poorly characterized and difficult to study, may be of fundamental im portance in cancer. In fact, our incapacity to understand the na ture of suppressor cells and their mode of action is one of the ma jor problems in immunology research today.
Challenging traditional views of arms dealers as agents of their own countries, Grant asserts that these firms pursued their own economic interests while convincing their home governments that weapon sales meant national prestige and influence. Grant tells how the resulting arms trade eventually led to an all-out arms race, and ultimately to war.
OKU 12 brings you a comprehensive synthesis of the latest clinical thinking and best practices across all orthopaedic specialty areas. Keep pace with the rapidly changing body of orthopaedic knowledge and clinical practice with OKU’s objective, balanced coverage in easily accessible formats, including new on-demand, fully-searchable digital versions.
The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure