Books by "José Maria Ruiz"
8 books found
Concepts and Models for Drug Permeability Studies
by Bruno Sarmento, Catarina Leite Pereira, José Das Neves
2024 · Elsevier
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules. - Summarizes the current advances in the use of permeability models in drug transport - Covers the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, renal, skin, and blood–brain barrier in vitro models. Includes case studies to facilitate understanding of various concepts in computer-aided applications - Updates in the second edition include organ-on-chip devices, 3D advanced models (multiple layered tissues, organoids, etc.), and multicompartmentalized tissue models
This text offers a brief introduction to the dispersion relations as an approach to calculate S-matrix elements, a formalism that allows one to take advantage of the analytical structure of scattering amplitudes following the basic principles of unitarity and causality. First, the case of two-body scattering is considered and then its contribution to other processes through final-state interactions is discussed. For two-body scattering amplitudes, the general expression for a partial-wave amplitude is derived in the approximation where the crossed channel dynamics is neglected. This is taken as the starting point for many interesting nonperturbative applications, both in the light and heavy quark sector. Subsequently crossed channel dynamics is introduced within the equations for calculating the partial-wave amplitudes. Some applications based on methods that treat crossed-channel dynamics perturbatively are discussed too. The last part of this introductory treatment is dedicated to the further impact of scattering amplitudes on a variety of processes through final-state interactions. Several possible approaches are discussed such as the Muskhelishvili-Omnes dispersive integral equations and other closed formulae. These different formalisms are then applied in particular to the study of resonances presenting a number of challenging properties. The book ends with a chapter illustrating the use of dispersion relations in the nuclear medium for the evaluation of the energy density in nuclear matter.
Is there a trade-off between deepening and widening? What do Europeans think?
by José Ignacio Torreblanca
2008 · CEPS
The stingless bees are the most diverse group of highly social bees and are key species in our planet’s tropical and subtropical regions, where they thrive. In Mexico, the management of stingless bees dates back centuries, and they were an essential part of the culture and cosmogony of native peoples like the Maya. In recent decades a vast amount of information has been gathered on stingless bees worldwide. This book summarizes various aspects of the biology and management of stingless bees, with special emphasis on the Mexican species and the traditions behind their cultivation. Much of the information presented here was produced by the author and the team of researchers at the Universidad Autónoma de Yucatán in the course of three decades of working with these insects. Given the breadth of its coverage, the book offers an equally valuable reference guide for academics, students and beekeepers alike.
Straits Used for International Navigation
by José Antonio de Yturriaga
1991 · Martinus Nijhoff Publishers
After an introductory chapter concerning the definition of Straits used for international navigation', the author examines in detail the evolution of the question in the years prior to the convening of UNCLOS-III, during the preparatory works of the Sea-Bed Committee and throughout the Conference. The second part of the book studies the legal norms set up by the 1982 UN Convention on the Law of the Sea concerning the regime of transit passage for maritime and air navigation applicable in most of the straits used for international navigation and the regime of innocent passage residually applied in the other straits. In the final chapter, the author makes a critical appraisal of the new regimes of navigation and overflight in straits, exposes the implications of such regimes in Spain, analyzes the applicability of the Convention's regulations before their coming into force, and examines the practice followed in the last few years by the most important States which favoured or opposed the regime of transit passage. From his position as Deputy-Head of the Spanish Delegation to the Law of the Sea Conference, Ambassador de Yturriaga participated from the very beginning in the work of UNCLOS-III and was an active protagonist in the debates of the straits' question. The book offers a first hand testimony of the straits' negotiation, which will be extremely useful for scholars and students of the Law of the Sea.
In Bolivia, politics have always shaped art, particularly when it comes to film. This book presents Bolivia's most significant filmmakers largely in their own words. Since 1981, José Sánchez-H. has personally interviewed most of the filmmakers featured and has consistently maintained a commitment to rigorous scholarship and attention to new developments. One of the first studies in English on Bolivian cinema, this work provides the non-Bolivian with important information about Bolivian cinema and its cultural and political context. The chapters flow from a broad profile of the country and its history through a chronological presentation of the history of Bolivian cinema to careful treatments of important films, filmmakers, and periods in Bolivian film history. Filmmakers treated include Antonio Eguino, Jorge Sanjines, Jorge Ruiz, Marcos Loayza, Paolo Agazzi, and Oscar Soria. Sanchez-H. includes information about every aspect of the cinema including the music. Appendixes include a chronology of the films and political events, a list of awards won by Bolivian films, and useful addresses.
Progress in Pattern Recognition, Image Analysis and Applications
by José Francisco Martínez-Trinidad
2006 · Springer Science & Business Media
This book constitutes the refereed proceedings of the 11th Iberoamerican Congress on Pattern Recognition, CIARP 2006, held in Cancun, Mexico in November 2006. The 99 revised full papers presented together with three keynote articles were carefully reviewed and selected from 239 submissions. The papers cover ongoing research and mathematical methods.