Intracellular Consequences of Amyloid in Alzheimer's Disease

by Michael R. D'Andrea

2016 · Academic Press

Consequences of Intracellular Amyloid in Alzheimer's Disease addresses one of the more currently unresolved aspects confounding Alzheimer's research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D'Andrea's first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer's Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. - Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer's - Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed - Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer's is initially a problem of amyloid, the neuron, or of the blood-brain barrier - Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer's

Musculoskeletal Interventions 3/E

by Barbara J. Hoogenboom, Michael L. Voight, William E. Prentice

2014 · McGraw Hill Professional

The definitive guide to designing and implementing evidence-based rehabilitation programs using therapeutic exercise -- updated in full color Musculoskeletal Interventions, 3rd Edition, is a comprehensive guide to the system considerations, design, implementation, and progression of rehabilitation programs for musculoskeletal injuries and dysfunction. Encompassing many aspects of musculoskeletal rehabilitation, with contributions from many renowned authors, it focuses on the practical application of theory in a clinical setting, making it valuable to both students and experienced physical therapists. Musculoskeletal Interventions features an easy-to-follow body region and functional approach to intervention strategies and is logically divided into five sections: Foundations of the Rehabilitation Process Addresses the important considerations in designing a rehabilitation program for the patient with a musculoskeletal injury Provides a guide-based overview of the rehabilitation process as well as an introduction to Clinical Reasoning and Algorithmic Thinking in rehabilitation Treating Physiologic Impairments During Rehabilitation Presents information on various physical impairments that may need to be addressed as part of the rehabilitation process The Tools of Rehabilitation Provides an overview of important rehabilitation tools and strategies Delivers detailed coverage of how these interventions should be incorporated into a rehabilitation program to achieve the individualized treatment goals for patients with musculoskeletal pathologies Intervention Strategies for Specific Injuries Covers specific rehabilitation techniques and interventions applied to the treatment of a wide variety of regional musculoskeletal injuries, dysfunctions, and post-operative conditions Special Consideration for Specific Patient Populations Discusses treatment considerations for specific patient populations, such as the geriatric patient, pediatric patient, and physically active female This edition is enhanced by a new full-color presentation, as well as the inclusion of valuable learning aids, such as clinical pearls, protocol grids, algorithms, learning objectives at the beginning of each chapter, and end-of-chapter treatment guidelines and references.

Enzymes as Targets for Drug Design

by Michael Palfreyman

2012 · Elsevier

Enzymes as Targets for Drug Design is a collection of scientific discussions related to enzyme inhibitors that show the many facets of the drug discovery process from the basic sciences through clinical applications. Topics include the biogenesis of phosphatidylinositol glycosyl membrane proteins, structure and catalytic function of ADP-ribose polymerase (ADPRT), and modulation of the dopaminergic system in cardiovascular therapeutics. The therapeutic utility of selected enzyme-activated irreversible inhibitors, the role of proteinases in the fibrosis of systemic sclerosis, and therapeutic opportunities in eicosanoid biosynthesis are also discussed. This book consists of 18 chapters and begins with examples of enzymes whose activities have recently been elucidated, or for which newer insights have been gleaned, but which do not yet have selective or potent inhibitors. The second part provides examples of enzymes where inhibitors have been identified but it is still not clear whether or not such an enzymatic blockade will be therapeutically beneficial. The final section describes clinical studies of newer, and not so new, enzyme inhibitors that are clearly of therapeutic importance. The therapeutic activity of monoamine oxidase inhibitors and the associated clinical issues are considered. This book is intended for clinicians as well as basic scientists in biochemistry, chemistry, pharmacology, and cell biology.

Integrating Multiple Literacies in K-8 Classrooms

by Janet C. Richards, Michael C. McKenna

2003 · Routledge

This text gives prospective and practicing teachers a comprehensive understanding of how to teach multiple literacies in elementary arid middle school classrooms. All of the Iiteracies—dance, music, visual arts, popular culture, media, and computer technologies—are integrated with reading and writing. Balanced treatment is given to theoretical perspectives and practical applications. The text also features authentic cases written by preservice teachers, and commentaries on the cases from practitioners and university professors. The cases are designed to prepare future teachers for the PRAXIS teacher certifying exam and others offered in many states. Three theoretical chapters support the practical applications: Chapter 1 addresses the benefits of writing and analyzing cases and the specific attributes of exemplary teaching cases, and offers guidelines for teachers to author their own case narratives and questions for analyzing and discussing case issues with peers; Chapter 2 discusses the role of electronic symbol making and multiple sign systems in children’s literacy and how children use symbols to receive and express meaning; Chapter 3 offers a theoretical framework that helps define and enable teachers to use the new literacies of Internet technology, and provides a strong rationale for expanding traditional definitions of literacy.

Mechanisms of Atmospheric Oxidation of the Oxygenates

by Jack Calvert, Abdelwahid Mellouki, John Orlando, Michael Pilling, Timothy Wallington

2011 · Oxford University Press

Prepared by an international team of eminent atmospheric scientists, Mechanisms of Atmospheric Oxidation of the Oxygenates is an authoritative source of information on the role of oxygenates in the chemistry of the atmosphere. The oxygenates, including the many different alcohols, ethers, aldehydes, ketones, acids, esters, and nitrogen-atom containing oxygenates, are of special interest today due to their increased use as alternative fuels and fuel additives. This book describes the physical properties of oxygenates, as well as the chemical and photochemical parameters that determine their reaction pathways in the atmosphere. Quantitative descriptions of the pathways of the oxygenates from release or formation in the atmosphere to final products are provided, as is a comprehensive review and evaluation of the extensive kinetic literature on the atmospheric chemistry of the different oxygenates and their many halogen-atom substituted analogues. This book will be of interest to modelers of atmospheric chemistry, environmental scientists and engineers, and air quality planning agencies as a useful input for development of realistic modules designed to simulate the atmospheric chemistry of the oxygenates, their major oxidation products, and their influence on ozone and other trace gases within the troposhere.

Schiff's Diseases of the Liver

by Eugene R. Schiff, Willis C. Maddrey, Michael F. Sorrell

2011 · John Wiley & Sons

For over 50 years covering 10 previous editions, Schiff's Diseases of the Liver has provided hepatologists with an outstanding evidence-based clinical reference work covering all aspects of liver disease, and is without doubt one of the world’s leading hepatology textbooks. Now fully revised and updated, it will serve as your first-stop reference for today’s demanding clinical situations. With a strong clinical focus, Schiff’s Diseases of the Liver covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes. Its enormous appeal has been due to the clarity of text, combined with the sheer thoroughness of its breadth of content. Key features include: An attractive full color design throughout Informative section overviews for each section Concise key concepts box in every chapter Treatment guidelines and management algorithms for every disease A full liver transplant section This 11th edition sees all existing chapters fully revised and refreshed with the very latest in clinical information from the world’s leading hepatologists. Also new to this edition is a companion website containing a variety of important extra materials, including: Approximately 100 multiple choice questions of the standard used in ABIM board exams in gastroenterology, to allow the user to self-assess their clinical knowledge All 450+ figures from the book in a high-quality, fully transportable and downloadable electronic format High-quality video clips of a variety of surgical procedures, all fully linked to the text 35 case studies featuring real-life clinical scenarios. Schiff’s Diseases of the Liver remains the key textbook for all gastroenterologists and hepatologists, in training or fully qualified, managing patients with liver disease.