The Molecular and Clinical Pathology of Neurodegenerative Disease

by Patrick A. Lewis, Jennifer E. Spillane

2018 · Academic Press

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. - Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders - Describes the clinical background and underlying molecular processes for Alzheimer's disease, Parkinson's, Prion, Motor Neuron, Huntington's, and Multiple Sclerosis - Highlights the state-of-the-art treatment options for each disorder - Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Tear Down the Walls

by Patrick Burke

2021 · University of Chicago Press

"Rock and roll's most iconic, not to mention wealthy, pioneers are overwhelmingly white, despite their great indebtedness to black musical innovators. Many of these pioneers were insensitive at best and exploitative at worst when it came to the black art that inspired them. Tear Down the Walls is about a different cadre of white rock musicians and activists, those who tried to tear down walls separating musical genres and racial identities during the late 1960s. Their attempts were often naïve, misguided, or arrogant, but they could also reflect genuine engagement with African American music and culture and sincere investment in anti-racist politics. Burke considers this question by recounting five dramatic incidents that took place between August 1968 and August 1969, including Jefferson Airplane's performance with Grace Slick in blackface on the Smothers Brothers Comedy Hour, Jean-Luc Godard's 1968 film, Sympathy for the Devil, featuring the Rolling Stones and Black Power rhetoric, and the White Panther Party at Woodstock. Each story sheds light on a significant but overlooked facet of 1960s rock-white musicians and audiences casting themselves as political revolutionaries by enacting a romanticized vision of African American identity. These radical white rock musicians believed that performing and adapting black music could contribute to what in the Black Lives Matter era is sometimes called "white allyship." This book explores their efforts and asks what lessons can be learned from them. As white musicians and activists today still attempt to find ethical, respectful approaches to racial politics, the challenges and victories of the 1960s can provide both inspiration and a sense of perspective"--

Advent to Pentecost

by Patrick Regan

2012 · Liturgical Press

Since 2007, use of the Roman Missal of 1962 has been broadly permitted within the church. This creates, in effect, two liturgical years running concurrently. In Advent to Pentecost, Abbot Patrick Regan compares the prayers and prefaces, readings and rubrics, calendar and chants of the 1962 Missal with those of the Missal as it was revised following the Second Vatican Council, now in its third edition. The result is a striking demonstration of the splendor and superiority of the reformed Missal over its predecessor, at least as far as the liturgical year is concerned. Regan's chapters on Advent, Lent, and the Easter Season are particularly informative because these seasons are so different in the two missals. Perhaps less obvious are the differences between Holy Week and the Triduum. Regan not only describes external modifications in the services as restored by Pius XII in 1956 but explores deeper theological currents, especially in the relationship between the passion and resurrection of the Lord in the one paschal mystery, to show how advances in this area find expression in the current Triduum celebrations and throughout the fifty days of Easter. The originality of the book lies mainly here. The most urgent liturgical challenge today, the author contends, is to raise the ars celebrandi to the same level of excellence as the Missal itself.