Books by "Robert L. Perlman"
5 books found
Distilling a set of practical principles from his forty years of experience as a pioneer in the computer industry, the author shows that innovation can be learned and practiced by everyone, that it can offer solutions to everyday problems as well as high-profile ones, and that it provides opportunities to solve business problems while meeting a variety of human needs.
Knowledge has been described as being like an expanding sphere with the volume of knowledge contacting a surface on the unknown. This new comprehensive review of the many fields of basic and clinical research that impact our understanding of multiple sclerosis has its basis in this premise. In doing research on MS, it is not enough to know clinical neurology or neurochemistry or neuroanatomy or pathology; it is important to understand the many other areas that relate to them. This volume provides an overview of MS-related research and will benefit many investigators in the field and help to advance our efforts to cure this, thus far intractable, disease. It is now more than 160 years since the first clinical-pathological descriptions of cases of multiple sclerosis and more than 130 years since the classic clinical description and development of diagnostic criteria by Charcot, yet MS remains an enigma. After decades of intense effort to find the cause, no cause has been clearly identified and the disease remains poorly understood. Despite the introduction of immunomodulatory therapies and immunosuppressive regimens, MS remains a devastating disease. While a great deal of progress has been made, much remains to be done. Our understanding of the disease remains limited, treatments remain inadequate, and comprehensive management all too rare. This volume is an overview of the basic sciences as they relate to MS and will provide clinicians and investigators a better understanding of the basic aspects of the disease. While it is possible to find excellent reviews of almost any aspect of MS, few attempts have been made to bring these very different aspects together in a single source. This volume is a companion to Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation, edited by Drs. Jack S. Burks and Kenneth P. Johnson. Together, they represent an attempt to comprehensively cover the field of MS from basic research to comprehensive management and to provide a broad overview for those interested in understanding the disease better or in pursuing MS research.
Animal Models for the Study of Human Disease
by Robert H. Miller, Sharyl Fyffe-Maricich, Andrew V. Caprariello
2013 · Elsevier Inc. Chapters
The most common demyelinating disease of the central nervous system (CNS) in the young adult population is multiple sclerosis (MS). MS is characterized by the focal loss of myelin sheaths in the brain and in the spinal cord of patients that is correlated with elevated activity of the immune system directed toward CNS antigens including myelin. The progression of MS is highly variable, but in many cases, it is characterized by a series of relapsing and remitting attacks that slowly increase residual functional deficit. Often, after several years, the disease transitions to a more progressive phenotype. Much of what is known about the pathology of MS is derived from a number of animal models. The most common animal model for the study of MS is experimental allergic encephalitis (EAE), which depending upon the host animal can present as relapsing/remitting or progressive disease. Although EAE has provided mechanistic insights implicating T-cell activation in the onset and progression of disease, understanding the mechanisms of pathology onset and myelin repair in the CNS require alternative models. One emerging hypothesis is that activation of T cells is secondary to pathogenesis of oligodendrocytes and animals models in which targeted loss of oligodendrocytes are beginning to reveal an understanding of the initiation of CNS demyelination. Myelin repair is difficult to study in the setting of EAE or oligodendrocyte pathogenesis; however, toxin models that result in localized demyelination as a consequence of direct injection or oral delivery have provided critical insights into cells of origin, timing, and molecular mechanisms guiding remyelination. Taken together, these three distinct model systems provide a strong basis for dissecting cell and molecular mechanism of demyelination as well as characterizing the efficacy of targeted therapeutics.
Neuropsychology for Psychologists, Health Care Professionals, and Attorneys
by Robert J. Sbordone, Ronald E. Saul, Arnold D. Purisch
2007 · CRC Press
Extensively revised and expanded, this third edition of Neuropsychology for Psychologists, Health Care Professionals, and Attorneys provides a clear, concise, and comprehensive discussion of neuropsychology, outlining its purpose, use, and historical development. It covers the anatomy of the brain, a wide variety of neurobehavioral disorders, compr
Insect Behavior is the second edition of the text that for thirty years served as the fundamental introduction to a field of study that has been growing enormously. Today, new technologies and understandings are allowing questions to be shaped—and answered—in ways that once could not have been envisioned. However, massive new information also can overwhelm and obscure the broader perspectives needed to put new discoveries into context. Thus, the times fairly demand that students and non-specialists seek a wider understanding of diverse proximate and ultimate forces that cause animals to behave as they do. This book provides that opportunity. The authors strike a balance between modern developments and historical insights, between new examples and old, between empirical work and theory, and between pertinent conclusions and the dynamic field and laboratory experiences from which such discoveries arise. Considerably updated and expanded, this edition includes 26 case studies, as well as 45 new color plates and 173 figures (over 40% of them new) with detailed legends that add richness to the well-written, accessible text. Like the course that originally inspired it, Insect Behavior will find utility at the graduate and senior undergraduate level for college and university students. However, although some background in entomology or animal behavior is helpful, an in-depth knowledge is not a prerequisite. Thus, the book also invites comparative psychologists, science educators, and all others with an interest in the physically small but inestimably important creatures that comprise three-quarters of all animal life on our planet.