Books by "Robert M. Thrall"
2 books found
Heresy is a central concept in the formation of Orthodox Christianity. Where does this notion come from? This book traces the construction of the idea of ‘heresy’ in the rhetoric of ideological disagreements in Second Temple Jewish and early Christian texts and in the development of the polemical rhetoric against ‘heretics,’ called heresiology. Here, author Robert Royalty argues, one finds the origin of what comes to be labelled ‘heresy’ in the second century. In other words, there was such as thing as ‘heresy’ in ancient Jewish and Christian discourse before it was called ‘heresy.’ And by the end of the first century, the notion of heresy was integral to the political positioning of the early orthodox Christian party within the Roman Empire and the range of other Christian communities. This book is an original contribution to the field of Early Christian studies. Recent treatments of the origins of heresy and Christian identity have focused on the second century rather than on the earlier texts including the New Testament. The book further makes a methodological contribution by blurring the line between New Testament Studies and Early Christian studies, employing ideological and post-colonial critical methods.
Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.