Books by "William D. Rubinstein"
6 books found
Lives of Victorian Political Figures, Part IV Vol 1
by Nancy LoPatin-Lummis, Michael Partridge, David Martin, William A Hay, Denys P Leighton
2021 · Routledge
First published in 2009, this is a collection of carefully selected extracts from biographies, memoirs, diaries, private letters and other ephemera reveal how these key nineteenth-century figures were viewed by their contemporaries. Volume 1 covers John Stuart Mill.
Antimicrobial Chemotherapy
by Roger Finch, Peter Davey, Mark H. Wilcox, William Irving
2012 · OUP Oxford
Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.
Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.
In the early 1970s few subjects in schools had grown faster than moral education, and more and more teachers were seeking guidance in a changing and developing field where a training in the ‘traditional’ subjects could not always provide sufficient help. Originally published in 1975, Dr Kay maintained that a study of the sociological factors involved could give considerable insight into the meaning and purpose of moral education, and in this book he examines the effect on the individual pupil of the home, the school and differing socio-economic class structures and ideologies. Using standard sociological analyses Dr Kay discloses some of the determinants of individual morality as they affect children in their homes and schools. He concludes that the alleged moral superiority of the middle-classes merely stresses the fact that the benefits which are currently enjoyed by this minority should become the privilege of all. The analysis of home and school leads him to the view that a democratic milieu is the environment most likely to promote moral growth. And his study of school systems concludes with the view that privileged elitism should be replaced by an ‘aristocracy of service’, with full pupil-participation in every aspect of school life. Today it can be read in its historical context.
Conquer - The Story of Ninth Army, 1944-1945
by Colonel Theodore W. Parker Jr., Colonel William J. Thompson
2016 · Lucknow Books
Conquer: The Story of Ninth Army recounts in great and glorious detail the U.S. Ninth army as it campaigned against Nazi Germany in Europe during World War II. The Ninth Army reached France in September 1944 in time to play a leading role in the reduction of Brest and Brittany; further battles awaited them during the November Offensive and the counterattack against the Ardennes offensive. Their march into Germany saw further bitter conflicts and actions along the Roer, the Rhine, the Ruhr and the Elbe, before the Ninth Army was finally able to rest as part of the occupation forces in defeated of Germany. Richly illustrated with photos and maps of the actions of the Ninth Army in the ETO. "Conquer: The Story of Ninth Army is intended to present in broad form a brief account of that Army's activities— tactical, administrative, and logistical. Considerations of space, time, and proportion have generally limited the mention of individual units to divisions and larger. In Ninth Army, however, as in any modern American army, these were only one-half of the troop strength. The other half comprised the large number of corps and army troops— cavalry, antiaircraft, engineer, chemical, field artillery, medical, military police, ordnance, quartermaster, signal, tank, and tank destroyer—the "supporting" troops, without whom the job could not have been done. And it is to these, most of whom wore the Ninth Army shoulder patch, that I wish to pay particular tribute here, without detracting in any way from the fine performance of the larger units."—Lt.-Gen. W. H. Simpson commander of the 9th Army.
Exosome Communication
by Dalapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C.S. Cho
2024 · Elsevier
Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing. - Comprehensive Coverage: Detailed exploration of the research history, development, and different isolation techniques of exosomes. - Therapeutic Applications: In-depth discussion of the diverse therapeutic applications of exosomes in health and disease. - Development Challenges: Insightful analysis of the challenges for the development of exosome nanovesicle-based formulations for drug delivery.