Obstetrics: Normal and Problem Pregnancies E-Book

by Mark B. Landon, Henry L. Galan, Eric R.M. Jauniaux, Deborah A. Driscoll, Vincenzo Berghella, William A. Grobman, Sarah J. Kilpatrick, Alison G. Cahill

2020 · Elsevier Health Sciences

Highly readable, well-illustrated, and easy to understand, Gabbe's Obstetrics: Normal and Problem Pregnancies is an ideal day-to-day reference or study tool for residents and clinicians. This 8th Edition of this bestselling text offers fast access to evidence-based, comprehensive information, now fully revised with substantial content updates, new and improved illustrations, and a new, international editorial team that continues the tradition of excellence established by Dr. Steven Gabbe. - Puts the latest knowledge in this complex specialty at your fingertips, allowing you to quickly access the information you need to treat patients, participate knowledgably on rounds, and perform well on exams. - Contains at-a-glance features such as key points boxes, bolded text, chapter summaries and conclusions, key abbreviations boxes, and quick-reference tables, management and treatment algorithms, and bulleted lists throughout. - Features detailed illustrations from cover to cover—many new and improved—including more than 100 ultrasound images that provide an important resource for normal and abnormal fetal anatomy. - Covers key topics such as prevention of maternal mortality, diabetes in pregnancy, obesity in pregnancy, vaginal birth after cesarean section, and antepartum fetal evaluation. - Provides access to 11 videos that enhance learning in areas such as cesarean delivery and operative vaginal delivery. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

Retrosynthesis in the Manufacture of Generic Drugs

by Pedro Paulo Santos, William Heggie

2020 · John Wiley & Sons

Offers a compendium of information on retrosynthesis and process chemistry, featuring innovative "reaction maps" showing synthetic routes of some widely used drugs This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the "best" processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of retrosynthesis and process chemistry—in order to show how retrosynthetic analysis assists in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process. The book also uses some key concepts used by process chemists to improve efficiency to indicate the best route to select. Each chapter in Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is dedicated to one drug, with each containing information on: worldwide sales and patent status of the Active Pharmaceutical Ingredient (API); structure analysis and general retrosynthetic strategy of the API; first reported synthesis; critical analysis of the processes which have been developed and comparison of the synthetic routes; lessons learned; reaction conditions for Schemes A to X; chemical "highlights" on key reactions used during the synthesis; and references. Drugs covered include: Gabapentin, Clopidogrel, Citalopram and Escitalopram, Sitagliptin, Ezetimibe, Montelukast, and Oseltamivir. Show how the retrosynthetic tool is used by the Pharmaceutical Industry Fills a gap for a book where retrosynthetic analysis is systematically applied to active pharmaceutical ingredients (APIs) Features analyses and methodologies that aid readers in uncovering practical synthetic routes to other drug substances, whether they be NCEs (New Chemical Entities) or generic APIs (Active Pharmaceutical Ingredients) Presents information from both the patent and academic literature for those who wish to use as a basis for further study and thought Features the use of "reaction maps" which display several synthetic processes in the same scheme, and which allow easy comparisons of different routes that give the same molecule or intermediate. A selection of these maps are available to download from: https://www.wiley.com/go/santos/retrosynthesis Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is an ideal book for researchers and advanced students in organic synthetic chemistry and process chemistry. It will also be of great benefit to practitioners in the pharmaceutical industry, particularly new starters, and those new to process chemistry.

Digital Water

by William Sarni

2021 · Routledge

This book shows how digital technologies are transforming how we locate, manage, treat, distribute, and use water. Water resources are under stress from over-allocation, increased demand, pollution, climate change, and outdated public policies. Historical approaches to delivering water for human consumption, industrial production, agriculture, power generation, and ecosystems are no longer adequate to meet demands. As a result, we need to vastly improve the efficiency and effectiveness of our public and private sector processes in water management. The author describes recent advances in data acquisition (e.g., satellite imagery, drones, and on-the-ground sensors and smart meters), big data analytics, artificial intelligence, and blockchain, which provide new tools to meet needs in both developing and developed economies. For example, a digital water technology portfolio brings the value of real-time system-wide monitoring – and response – within the capability of water providers of all sizes and sophistication. As such, digital water promises to increase the long-term value of water resource assets while assisting in compliance with regulations and helping respond to the demands of population growth and evolving natural and business ecosystems. Including many practical examples, the author concludes that digital and smart water technologies will not only better manage water assets but also enable the public sector to provide universal access to safe drinking water, the private sector to continue to grow, and ecosystems to thrive.

Modern Optical Spectroscopy

by William W. Parson

2015 · Springer

This textbook offers clear explanations of optical spectroscopic phenomena and shows how spectroscopic techniques are used in modern molecular and cellular biophysics and biochemistry. The topics covered include electronic and vibrational absorption, fluorescence, resonance energy transfer, exciton interactions, circular dichroism, coherence and dephasing, ultrafast pump-probe and photon-echo spectroscopy, single-molecule and fluorescence-correlation spectroscopy, Raman scattering, and multiphoton absorption. This revised and updated edition provides expanded discussions of quantum optics, metal-ligand charge-transfer transitions, entropy changes during photoexcitation, electron transfer from excited molecules, normal-mode calculations, vibrational Stark effects, studies of fast processes by resonance energy transfer in single molecules, and two-dimensional electronic and vibrational spectroscopy. The explanations are sufficiently thorough and detailed to be useful for researchers and graduate students and advanced undergraduates in chemistry, biochemistry and biophysics. They are based on time-dependent quantum mechanics, but are developed from first principles with a clarity that makes them accessible to readers with little prior training in this field. Extra topics and highlights are featured in special boxes throughout the text. The author also provides helpful exercises for each chapter.